Ονοματεπώνυμο: ΜΑΡΙΑ ΤΣΑΧΑΚΗ
Ημερομηνία γέννησης: 12/12/1982
Τηλέφωνο: 210-7274926
e-mail: mtsachaki@yahoo.gr
2005-σήμερα: Εκπόνηση διδακτορικής διατριβής στο τμήμα Βιολογίας του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών με θέμα <<Μελέτη των πρωτεΐνικών αλληλεπιδράσεων της πρωτεΐνης BRI2>>, με επιβλέποντα τον Αναπληρωτή Καθηγητή του Πανεπιστημίου Αθηνών Σπύρο Ευθυμιόπουλο.
2005: Αποφοίτηση από το Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών, Σχολή Θετικών Επιστημών, Τμήμα Βιολογίας.
Ερευνητικά ενδιαφέροντα: Μελέτη του φυσιολογικού ρόλου της πρωτεΐνης BRI2, η οποία εμπλέκεται στις άνοιες τύπου Βρετανίας και Δανίας. Οι άνοιες αυτές εμφανίζουν ιδιαίτερο ενδιαφέρον καθώς παρουσιάζουν σημαντικές νευροπαθολογικές ομοιότητες με την πιο κοινή μορφή άνοιας, που είναι η νόσος Alzheimer.
Ανακοινώσεις σε συνέδρια
1. Tsachaki M. , Melachroinou K. , Kyrargyri V. , Rostagno A. , Ghiso J. & Efthimiopoulos S. BRI2 homodimerizes with the involvement of disulfide bonds. Federation of European Neuroscience Societies (FENS) meeting, Geneva, Switzerland, July 1008 (poster).
2. Serlidaki D., Tsachaki M., Efthimiopoulos S. Glycozylation of BRI2 at asparigine 170 regulates its cell surface expression. 29th Scientific Conference of the Hellenic Society for Biological Sciences, Τhessaloniki, Greece, May 2008 (poster).
3. Toli D., Tsachaki M., Efthimiopoulos S. Study of BRI2-ADAM10 interaction. 29th Scientific Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Greece, May 2008 (poster).
4. Tsachaki M., Melachrοinou C., Kyrargyri V., Efthimiopoulos S. BRI2 protein forms homodimers with the involvement of disulfide bonds and non covalent interactions. 29th Scientific Conference of the Hellenic Society for Biological Sciences, Thessaloniki, Greece, May 2008 (poster).
5. Tsachaki M., Melachroinou C., Toli D., Efthimiopoulos S. (2007). The BRI2 protein forms homodimers with the contribution of disulfide bonds. 28th Scientific Conference of the Hellenic Society for Biological Sciences, Kavala, Greece, May 2007 (poster).
6. Tsachaki M., Melachroinou C., Kyrargyri V., Efthimiopoulos S. (2007). Cysteine at position 89 and non-covalent interactions participate in the homodimerization of BRI2 protein that are expressed in the cell surface. 28th Scientific Conference of the Hellenic Society for Biological Sciences, Kavala, Greece, May 2007 (poster).
7. Tsachaki M., Fotinopoulou A., Vlavaki M., Poulopoulos A., Rostagno A., Franzione B., Ghiso J., Efthimiopoulos S. (2006). BRI2 modulates Amyloid Precursor Protein processing and inhibits Aβ generation. 10th International Conference on Alzheimer’s Disease and Related Disorders. Madrid, Spain, July 15-20, 2006. (προφορική ανακοίνωση).
8. Fotinopoulou A., Tsachaki M., Vlavaki M., Rostagno A., Franzione B., Ghiso J., Efthimiopoulos S. (2006). “Neurodegenerative Diseases: Similarities in Pathology Suggest Common Molecular Mechanisms Leading to Neuronal Death”. International Symposium “Neurobiology Today”, Belgrade, Serbia&Montenegro.
9. Vlavaki M., Tsachaki M., Ghiso J., Efthimiopoulos S. (2006). BRI2 interacts with BACE2 which is involved in the processing of amyloid precursor protein. 20th Meeting of the Hellenic Society for Neuroscience. Irakleio, Greece, September 29-October 1, 2006 (poster).
10. Tsachaki M., Melachroinou C., Ghiso J., Efthimiopoulos S. (2006). Disulphide bonds between cysteines contribute to the homodimerization of BRI2 protein. 20th Meeting of the Hellenic Society for Neuroscience. Irakleio, Greece, September 29-October 1, 2006 (poster).
11. Fotinopoulou A., Tsachaki M., Vlavaki M., Rostagno A., Franzione B., Ghiso J., Efthimiopoulos S. (2006). BRI2 regulates APP processing by interacting and destabilizing BACE1. 28th Scientific Conference of the Hellenic Society for Biological Sciences, Ioannina, Greece, May 2006 (poster).
12. Tsachaki M., Melachrinou C., Ghiso J., Efthimiopoulos S. (2006). The formation of disulphide bonds between cysteines contributes to the homodimerization of BRI2 protein. 28th Scientific Conference of the Hellenic Society for Biological Sciences, Ioannina, Greece, May 2006 (poster).
13. Fotinοpoulou A., Tsachaki M., Ghiso J., Efthimiopoulos S. (2005). The BRI protein induces BACE catabolism and reduces levels of amyloid-β protein. 27th Scientific Conference of the Hellenic Society for Biological Sciences, Nafplio, Greece, May 2005 (poster).
Δημοσιεύσεις σε διεθνή περιοδικά
1. Fotinopoulou A., Tsachaki M., Vlavaki M., Poulopoulos A., Rostagno A., Frangione B., Ghiso J., and Efthimiopoulos S. (2005). BRI2 Interacts with Amyloid Precursor Protein (APP) and Regulates Amyloid β (Aβ) Production. J Biol Chem 280:30768-30772. Δείκτης Βαρύτητας: 5,581.
2. Tsachaki Μ., Ghiso J., Rostagno A., Efthimiopoulos S. (2007). BRI2 homodimerizes with the involvement of intermolecular disulfide bonds. Neurobiol of aging. Δείκτης βαρύτητας: 5,607.
Κεφάλαια σε βιβλία
Tsachaki M., Fotinopoulou A., Vlavaki M., Rostagno A.1, 1Frangione B.1, Ghiso J.1,. and Efthimiopoulos S. (2007). Neurodegenerative diseases: Similarities in pathology suggest common molecular mechanism leading to neuronal death. Proceeding of the Neurobiology Today Symposium. Editors: Sabera Ruzdijic and Selma Kanazir, Belgrade, Serbia.
Υποτροφίες
Υπότροφος του Ιδρύματος Κρατικών Υποτροφιών από το Νοέμβριο του 2007 ως σήμερα.